Dr. Pradip De is a Senior Scientist and Head of Translational Oncology at the Avera Cancer Institute, Center for Precision Oncology, in Sioux Falls, South Dakota. By training, he is a signal transduction biologist. His primary focus of research is to investigate the signal-processing and resistance mechanisms in tumor cells, especially in subtype-specific breast cancer model. He is deeply involved in developing a comprehensive precision medicine focused treatment strategy based on actionable genetic alterations of patients’ tumor samples. In his day to day professional life, he tries to strengthen clinical decision-making by aligning specific mutations with targeted drugs on a case to case basis. Dr. De is also Assistant Professor in the Department of Internal Medicine at the University of South Dakota, Sanford School of Medicine. His experiences in the field of signal transduction pathway research include prior appointments at the Emory School of Medicine, pediatric hematology/oncology in the Department of Pediatrics, AFLAC Cancer Center and Blood Disorder Services (in Emory). He was a post-doctoral research fellow at the Herman B. Wells Center for Pediatric Research, Purdue University. Over the course of his 25-year career in cancer research (in both industry and academia), Dr. De has authored more than 50 peer-reviewed articles, editorials and book chapters. He has presented his research at leading international conferences, including ASCO, the World Wide Innovation Network Annual Meeting, with more than 100 accepted abstracts. Dr. De reviews original research articles for several journals, including FEBS letters, Cancer Research, Clinical Cancer Research, the British Journal of Cancer, Oncologist and Molecular Cancer Therapeutics.